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a) contacting the sample which has a nucleic acid probe or primer which selectively hybridizes into the nucleic acid molecule; and
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comprising culturing the host mobile of assert 5 less than ailments through which the nucleic acid molecule is expressed.
a) speaking to a polypeptide, or perhaps a cell expressing a polypeptide of declare eight which has a check compound; and
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Amino acid residues that are not conserved or only semiconserved among the Tango- 77 of assorted species can be non-essential for exercise and thus would possible be targets for alteration.
[0151] Along with the formulations described Beforehand, the compounds might also be formulated for a depot preparation. These types of extensive performing formulations could be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection.
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To this conclusion, various amino acid substitutions at 1 or both of the 1st or third amino acid positions of any one or more of your glycosylation recognition sequences which arise, and/or an amino acid deletion at the second placement of any a number of of these kinds of recognition sequences, will prevent glycosylation with the modified tripeptide sequence (see, for instance, Miyajima et al., EMBO J. five:1193, 1986).
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thirteen. A method for detecting the existence of a polypeptide of assert 8 in a sample, comprising: a) getting in touch with the sample with a compound which selectively binds to your polypeptide of claim eight; and b) identifying whether the compound binds to your polypeptide inside the sample.